Selected Peer-Reviewed Publications (in chronological order)
Selker HP, Griffith JL, Dorey FJ, D'Agostino RB. How do physicians adapt when the coronary care unit is full? A prospective multicenter clinical study. JAMA. 1987;257:1181-1185.
Selker HP, Griffith JL, D'Agostino RB. A tool for judging coronary care unit admission appropriateness valid for both real-time and retrospective use: A time-insensitive predictive instrument (TIPI) for acute cardiac ischemia: A multicenter study. Med Care. 1991;29:610-627.
Selker HP, Griffith JL, D'Agostino RB. A time-insensitive predictive instrument for acute myocardial infarction mortality: A multicenter study. Med Care. 1991;29:1196-1211.
Jayes RL, Larsen GC, Beshansky JR, D'Agostino RB, Selker HP. Physician electrocardiogram reading in the ED. Accuracy and effect on triage decisions: a multicenter study. J Gen Intern Med. 1992;7:387-392.
Selker HP. Systems for comparing actual and predicted mortality rates: Characteristics to promote cooperation in improving hospital care. Ann Intern Med. 1993;118:820-822.
Fibrinolytic Therapy Trialists' (FTT) Collaborative Group (including Selker HP). Indications for fibrinolytic therapy in suspected acute myocardial infarction: Collaborative overview of early mortality and major morbidity results from all randomized trials of more than 1000 patients. Lancet. 1994;343:311-322.
Selker HP, Beshansky JR, Schmid CS, Griffith JL, et al. Presenting pulse pressure predicts thrombolytic therapy-related intracranial hemorrhage: TPI project results. Circulation. 1994;90:1657-1661.
Selker HP, Griffith JL, Patil S, Long WJ, D’Agostino, RB. A comparison of performance of mathematical predictive methods for medical diagnosis. J Investig Med. 1995;43:468-476.
Aufderheide TP, Rowlandson I, Lawrence SW, Kuhn EM, Selker HP. A test of the acute cardiac ischemia time-insensitive predictive instrument (ACI-TIPI) for prehospital use. Ann Emerg Med. 1996;27:193-198.
Maynard C, Beshansky JR, Griffith JL, Selker HP. The influence of sex on the use of cardiac procedures in patients presenting to the emergency department: A prospective multicenter study. Circulation. 1996;94:93-98.
Katz DA, Beshansky JR, Griffith JL, Selker HP. The use of empiric clinical data in the evaluation of practice guidelines of unstable angina. JAMA. 1996;276:1568-1574.
Selker HP, Zalenski RJ. An evaluation of technologies for detecting acute cardiac ischemia in the emergency department: A report of the NIH national heart attack alert program. Ann Emerg Med. 1997;29:1-87.
Zucker DR, Griffith JL, Beshansky JR, Selker HP. Presentations of acute myocardial infarctions in men and women: Results from a prospective, multicenter study. J Gen Intern Med. 1997;12:79-87.
Coronado BE, Griffith JL, Beshansky JR, Selker HP. Hospital mortality in women and men with acute cardiac ischemia: A prospective multicenter study. J Am Coll Cardiol. 1997;29:1490-1496.
Dracup K, Alonzo AA, Atkins JM, Selker HP, et al. The physician's role in minimizing prehospital delay in patients at high risk for acute myocardial infarction. Ann Intern Med. 1997;126:645-651.
Schmid CH, D'Agostino RB, Griffith JL, Beshansky JR, Selker HP. A logistic regression model when some events precede treatment: Effect of thrombolytic therapy for AMI on risk of cardiac arrest. J Clin Epidemiol. 1997;50:1219-1229.
Selker HP, Griffith JL, Beshansky JR, et al. Patient-specific predictions of outcomes in myocardial infarction real-time emergency use: A thrombolytic predictive instrument. Ann Intern Med. 1997;127:538-556.
Maynard C, Beshansky JR, Griffith JL, Selker HP. Causes of chest pain and symptoms suggestive of acute cardiac ischemia in African American patients presenting to the ED. J Natl Med Assoc. 1997;89:665-671.
Selker HP, Beshansky JR, Griffith JL, et al. Use of the acute cardiac ischemia time-insensitive predictive instrument (ACI-TIPI) to assist with triage of patients with chest pain or other symptoms suggestive of acute cardiac ischemia: A multicenter, controlled clinical trial. Ann Intern Med. 1998;129:845-855.
Pope JH, Aufderheide TP, Ruthazer R, Woolard RH, Feldman JA, Beshansky JR, Griffith JL, Selker HP. A multicenter prospective study of missed diagnoses of acute myocardial infarction and unstable angina pectoris in the emergency department. N Engl J Med. 2000;342:1163-1170.
Zalenski RJ, Selker HP, Cannon CP, et al. National heart attack alert program position paper: Chest pain centers and programs for the evaluation of acute cardiac ischemia. Ann Emerg Med. 2000;35:462-471.
Feldman JA, Fish SS, Beshansky JR, Griffith JL, Woolard RH, Selker HP. Acute cardiac ischemia in patients with cocaine-associated complaints: Results of a multicenter trial. Ann Emerg Med. 2000;36:469-476.
Selker HP, Beshansky JR, Griffith JL, for the TPI Trial Investigators. Use of the electrocardiograph-based thrombolytic predictive instrument (TPI) to assist thrombolytic and reperfusion therapy for acute myocardial infarction: A multicenter randomized clinical effectiveness trial. Ann Intern Med. 2002;137:87-95.
Kent DM, Hayward RA, Griffith JL, Sandeep V, Beshansky JR, Califf RM, Selker HP. An independently derived and validated predictive model for selecting patients with myocardial infarction who are likely to benefit from tissue plasminogen activator compared with streptokinase. Am J Med. 2002. 113:105-111.
Udelson JE, Beshansky JR, Ballin DS, Feldman JA, Griffith JL, Heller GV, Hendel RC, Pope JH, Ruthazer R, Spiegler EJ, Woolard RH, Handler J, Selker HP. Myocardial perfusion imaging for evaluation and triage of patients with suspected acute cardiac ischemia: A randomized controlled trial. JAMA. 2002;288:2693-2700.
Selker HP, Raitt MH, Schmid CH, Laks MM, Beshansky JR, Griffith JL, et al. Time-dependent predictors of primary cardiac arrest in patients with acute myocardial infarction. Am J Cardiol. 2003;91:280-286.
Kent DM, Ruthazer R, Selker HP. Are some patients likely to benefit from recombinant tissue-
type plasminogen activator for acute ischemic stroke even beyond 3 hours from symptom onset? Stroke. 2003;34:464-467.
Savvides PS, Terrin NC, Erban J, Selker HP. Development and validation of a patient-specific predictive instrument for the need for dose reduction in chemotherapy for breast cancer: a potential decision aid for the use of myeloid growth factors. Support Care Cancer. 2003;11(5) :313-320.
Terrin NC, Schmid CH, Griffith JL, D’Agostino RB, Selker HP. External validity of predictive models: Comparison of Logistic regression, classification trees, and neural networks. J Clin Epidemiol. 2003;56:721-729.
Kent DM, Hinchey J, Price LL, Levine SR, Selker HP. In acute ischemic stroke, are asymptomatic intracranial hemorrhages clinically innocuous? Stroke. 2004;35(5):1141-46.
Kent DM, Price LL, Ringleb P, Hill MD, Selker HP. Sex-based differences in response to recombinant tissue plasminogen activator in acute ischemic stroke: a pooled analysis of randomized clinical trials. Stroke. 2005;36(1):62-65.
Udelson JE, Selker HP. Invited Editorial. Quantitative Instruments for Predicting Risk...and Benefit. J Am Coll Cardiol. 2005;45(5):730-732.
Abourjaily P, Gouveia W, Selker HP, Zucker DR. Evaluating the Nondrug Costs of Formulary Coverage Restrictions. Manag Care. 2005;14(8):50-57.
Dansinger ML, Gleason JA, Griffith JL, Selker HP, Schaefer EJ. Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: A randomized trial. JAMA. 2005; 293(1):43-53.
Katz DA, Williams G, Brown RL, Aufderheide T, Bogner M, Rahko PR, Selker HP. Emergency physicians' fear of malpractice in evaluating patients with possible acute cardiac ischemia. Ann Emerg Med. 2005;4(6): 525-33.
Katz DA, Aufderheide TP, Bogner M, Rahko PR, Brown RL, Brown LM, Prekker ME; Selker HP. The impact of unstable angina guidelines in the triage of emergency department patients with possible acute coronary syndrome. Med Decis Making. 2006;26:6-6-616.
Milch C, Selker HP, Kent D, Ruthazer R, et al. Differences in triage thresholds for patients presenting with possible acute coronary syndromes: more than meets the eye. J Invest. Med. 2006;54(2):76-85.
Westfall JM, Van Vorst RF, McGloin J, Selker HP. Triage and diagnosis of chest pain in rural hospitals: implementation of the ACI-TIPI in the High Plains Research Network. Ann Fam Med. 2006;4:153-158.
Kent DM, Ruthazer R, Griffith JL, Beshansky JR, Grines CL, Aversano T, Concannon TW, Zalenski RJ, Selker HP. Comparison of mortality benefit of immediate thrombolytic therapy versus delayed primary angioplasty for acute myocardial infarction. Am J Cardiol. 2007;99:1384-1388.
Katz DA, Dawson J, Beshansky JR, Rahko PS, Aufderheide TP, Bogner M, Tighouart H, Selker HP. Does concordance with guideline triage recommendations impact clinical care of patients with possible acute coronary syndrome? Med Decis Making. 2007;27:423-437.
Katz DA, Aufderheide T, Bogner M, Rahko PR, Selker HP. Do Emergency Department Patients with Possible Acute Coronary Syndrome have Better Outcomes when Admitted to Cardiology? Ann Emerg Med. 2008;51:561-570.
Kent DM, Ruthazer R, Griffith JL, Beshansky JR, Grines CL, Aversano T, Concannon TW, Zalenski RJ, Selker HP. A percutaneous coronary intervention thrombolytic predictive instrument (PCI-TPI) to assist choosing between immediate thrombolytic therapy versus delayed primary percutaneous coronary intervention for acute myocardial infarction. Am J Cardiol. 2008;101(6):790-795.
Hinchey JA, Shephard T, Tonn ST, Ruthazer R, Selker HP, Kent DM. Benchmarks and determinants of adherence to stroke performance measures. Stroke. 2008;39(5):1619-20.
Ricciardi R, Roberts PL, Marcello PW, Selker HP, Baxter N. Disparate use of minimally invasive surgery in benign surgical conditions. Surg Endosc. 2008 Jul 2 [Epub ahead of print] PMID:18594921.
Ricciardi R, Virnig BA, Ogilvie JW Jr, Dahlberg PS, Selker HP, Baxter NN. Volume-outcome relationship for coronary artery bypass grafting in an era of decreasing volume. Arch Surg. 2008;143(4):338-44.
Active Research Support/Grants
UL1 RR025752 (Selker)
5/19/08-4/30/13
NIH/NCRR
Tufts Clinical and Translational Science Institute (CTSI)
This Clinical and Translational Science Award will support and instill the culture of cooperative interdisciplinary research by creating a new home for clinical and translational research across the University and clinical affiliates.
KL2 RR025751 (Selker)
5/19/08-4/30/13
NIH/NCRR
Tufts Clinical and Translational Science Institute (CTSI)
This portion of the CTSI provides research training for clinical faculty at the clinical affiliates.
No grant number (Selker)
7/1/07-12/31/10
Pfizer, Inc.
Tufts-NEMC Career Development Award
This project aims to train postdoctoral fellows and junior faculty scholars to be leaders in health services and outcomes research and evidence-based medicine.
U01 HL077821 (Selker)
9/1/04-8/31/09
NIH/NHLBI
Early EMS and ED Use of GIK for ACS: The IMMEDIATE Trial
This is one of four NIH grants that together support the conduct of the IMMEDIATE Trial. This project is a multi-center randomized placebo-controlled clinical trial to test the impact of intravenous glucose, insulin and potassium (GIK) in the prehospital emergency medical service setting for acute coronary syndromes (ACS). It is hypothesized that this treatment, administered as early as possible in ACS, will reduce short-term (30-day) and long-term (1-year) mortality, compared to usual treatment alone.
T32 HS00060 (Selker)
9/30/93-6/30/09
AHRQ
Postdoctoral Fellowships in Health Services Research
This project seeks to train those who will be leaders and innovators in the application of methods of health services research, especially to the direct improvement of clinical practice.
